WebLorazepam (PO/IV): 0.025 - 0.1 mg/kg/dose (Max: 2 mg) Q4-6 Midazolam (PO) 0.25 - 0.5 mg/kg/dose (Max: 20 mg) PRN Voriconazole (IV/PO) 2 - 12 yo: 9 mg/kg/dose x 2 doses then 8 -9 mg/kg/dose Q12 12 yo: 6 mg/kg/dose x 2 doses then 3 - unspecified interaction mechanism. Monitor Closely (1)lemborexant, lorazepam. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Use Caution/Monitor. Monitor Closely (1)lorazepam and sufentanil both increase sedation. Use Caution/Monitor. Monitor Closely (1)acrivastine and lorazepam both increase sedation. Use Caution/Monitor. Either increases effects of the other by sedation. Modify Therapy/Monitor Closely. Monitor Closely (1)lorazepam increases and propylhexedrine decreases sedation. This drug works by enhancing the effects of a certain natural chemical in the body (GABA). Use Caution/Monitor. Use Caution/Monitor. We may also administer beta-blockers and melatonin to alleviate some additional effects of anxiety, such as a rapid heart beat or insomnia. Use Caution/Monitor. If any of these effects last or get worse, tell your doctor or pharmacist promptly.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Monitor closely for signs of respiratory depression and sedation. Use Caution/Monitor. Compare it to your result computed with our benzodiazepine conversion calculator. Monitor Closely (1)clemastine and lorazepam both increase sedation. Use Caution/Monitor. lorazepam and doxylamine both increase sedation. STOP-BANG calculator screens for the risk factors & symptoms of obstructive sleep apnea (OSA). Some conditions may become worse when this drug is abruptly stopped. Use Caution/Monitor. Dose Equivalent to 10 mg Diazepam Available Tablet Strengths Duration of Action* Half-Life** (hours) Alprazolam (Xanax) 0.5-1 mg 0.25 mg, Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Minor/Significance Unknown. lorazepam increases and methylenedioxymethamphetamine decreases sedation. x}n y)Zn91Iv l38Y8bIkYbX$=x:9\>?}st_~xOo^\~dt&&=\~o~g/}~y%;]V|s{h+j/~\f'iqriwZgI~IOk[b,n6'K+%Y{Y?k{]U4{H}mWRa |3}ktz_>iCy>VbZ{SZ(_!> _~{pz.5'Kxo'wW0P*okGa? Use Caution/Monitor. Monitor Closely (1)lorazepam increases and epinephrine racemic decreases sedation. Studies have shown that the combination of benzodiazepines and buprenorphine altered the usual ceiling effect on buprenorphine-induced respiratory depression, making the respiratory effects of buprenorphine appear similar to those of full opioid agonists. Use Caution/Monitor. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. WebNAME Generic (Brand) Approx. Before Monitor Closely (1)lorazepam and diamorphine both increase sedation. Webpharmacist for any questions about appropriate conversion doses. lorazepam increases and dopexamine decreases sedation. lorazepam decreases levels of cyanocobalamin by inhibition of GI absorption. lorazepam and marijuana both increase sedation. Search for Similar Articles WebPeak plasma levels were reached at 1.15 hr after dosage, with absorption half-life averaging 14.2 (+/- 4.7) min. A: Generally acceptable. 0000000856 00000 n Talk to your doctor or pharmacist about lifestyle changes that might benefit you.Do not share this medication with others. lorazepam increases and dobutamine decreases sedation. Use Caution/Monitor. Use Caution/Monitor. Either increases effects of the other by sedation. }0CGIW>8BFg\ Rw$@4}whkO1kp$} iX{ RxV ;*@8'S+t'OVC 9m:_a@Bg/MGOBZx%+|V|KgT5|*Vz0b ohaKGZ Complications of sedation with midazolam in the intensive care unit and a comparison with other sedative regimens. Monitor Closely (1)lorazepam and buprenorphine buccal both increase sedation. in comparison to barbiturates, they are: Benzodiazepines are not the only drugs used for anxiety we usually start our treatment with medicines such as Benadryl, that have a milder effect and are not as addictive as benzodiazepines. Also, lorazepam may have the opposite of its usual calming effect in older adults (see also Side Effects section).This drug may have the opposite of its usual calming effect in children, causing restlessness, shaking, or mental/mood changes (such as agitation, hallucinations).Tell your doctor if you are pregnant or plan to become pregnant. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity. butabarbital and lorazepam both increase sedation. Effect of interaction is not clear, use caution. This work was performed at the Childrens Hospital of Philadelphia. Use Caution/Monitor. Consult your doctor for more details. Read more about Benadryl by visiting the benadryl calculator. Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics. Kim PM, Weinstein SL. lorazepam and daridorexant both increase sedation. Minor (1)lorazepam decreases effects of onabotulinumtoxinA by pharmacodynamic antagonism. Your dose may need to be gradually decreased.When this medication is used for a long time, it may not work as well. Monitor Closely (1)oliceridine, lorazepam. 0000008055 00000 n Use Caution/Monitor. Modify Therapy/Monitor Closely. Monitor Closely (1)lorazepam and pimozide both increase sedation. In: * Article titles in AMA citation format should be in sentence-case, You can cancel anytime within the 30-day trial, or continue using Johns Hopkins Guides to begin a 1-year subscription ($39.95). Limit dosages and durations to the minimum required. Monitor Closely (1)lorazepam and flibanserin both increase sedation. Why are benzodiazepines so popular? Select Try/Buy and follow instructions to begin your free 30-day trial. NCI CPTC Antibody Characterization Program. stream Monitor Closely (1)lorazepam increases and dexmethylphenidate decreases sedation. :Bn,^&8~z~-_B To prevent withdrawal, your doctor may lower your dose slowly. Minor/Significance Unknown. Monitor Closely (1)teduglutide increases levels of lorazepam by Other (see comment). Coadministration enhances CNS depressant effects. Coadministration may result in hypotension, profound sedation, respiratory depression, coma, and death. Use Caution/Monitor. Both drugs can cause metabolic acidosis. Modify Therapy/Monitor Closely. Use Caution/Monitor. lorazepam and amoxapine both increase sedation. Use Caution/Monitor. lorazepam decreases effects of pancuronium by pharmacodynamic antagonism. Minor (1)lorazepam decreases effects of atracurium by pharmacodynamic antagonism. If a benzodiazepine must be used for an indication other than seizures, lower the benzodiazepine initial dose and cautiously titrate to clinical response. PRECAUTIONS: Before taking lorazepam, tell your doctor or pharmacist if you are allergic to it; or to other benzodiazepines (such as alprazolam, clonazepam, diazepam); or if you have any other allergies. Monitor Closely (1)pentobarbital and lorazepam both increase sedation. Other (see comment). Minor (1)lorazepam increases effects of vinpocetine by unspecified interaction mechanism. Anxiolytics: past, present, and future agents. Usual dose: 2-6 mg/day in divided doses. WebConverting from: ALPRAZolam (Xanax) ChlordiazePOXIDE (Librium) DiazePAM (Valium) ClonazePAM (KlonoPIN) LORazepam (Ativan) Oxazepam (Serax) Temazepam (Restoril) Triazolam (Halcion) Total daily drug dosage (mg) mg Converting to: ALPRAZolam lorazepam decreases levels of acetaminophen IV by increasing metabolism. Minor (1)lorazepam decreases effects of pancuronium by pharmacodynamic antagonism. Instead, skip the missed dose. lorazepam and chloral hydrate both increase sedation. Use Caution/Monitor. lorazepam increases and phenylephrine PO decreases sedation. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Use Caution/Monitor. Minor (1)gemifloxacin increases levels of lorazepam by decreasing metabolism. and formulary information changes. Effect of interaction is not clear, use caution. lorazepam and ethanol both increase sedation. Use Caution/Monitor. Benzodiazepine exposure in pregnancy and risk of major malformations: a critical overview. Effect of interaction is not clear, use caution. Monitor Closely (1)lorazepam and trazodone both increase sedation. Use Caution/Monitor. The median Withdrawal Assessment ToolVersion 1 scores pre conversion and post conversion were not significantly different (1 [interquartile range, 0.752] and 1 [interquartile range, 0.252], respectively, p = 0.1). Effect of interaction is not clear, use caution. WebBenzodiazepine Dose and Route Equivalence Diazepam 10mg PO/PR 2.5mg subcut midazolam Clonazepam 1mg PO/SC Lorazepam 1mg PO/IV Oxazepam 15 to 30mg PO Temazepam 10mg PO Midazolam Nasal Spray 5 sprays (=2.5mg) Example: A patient has been taking 1 mg lorazepam PO (equivalent to 2.5 mg subcut midazolam) + used Monitor Closely (1)suvorexant and lorazepam both increase sedation. Profound sedation, respiratory depression, coma, and death may result if coadministered. Some error has occurred while processing your request. We're going to present a definitive benzo conversion chart, benzodiazepines classification, and the details of every drug's mode of action. This information does not assure that this product is safe, effective, or appropriate for you. lorazepam and clomipramine both increase sedation. Most Interventions: Modify Therapy/Monitor Closely. 0000003552 00000 n Use Caution/Monitor. Use Caution/Monitor. Serious - Use Alternative (1)sufentanil SL, lorazepam. Please enable it to take advantage of the complete set of features! Use Caution/Monitor. Davidson JR. Use of benzodiazepines in social anxiety disorder, generalized anxiety disorder, and posttraumatic stress disorder. Use Caution/Monitor. lorazepam and dantrolene both increase sedation. lorazepam and oxazepam both increase sedation. Use Caution/Monitor. In some cases, monitoring at a higher level of care for tapering CNS depressants may be appropriate. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Minor/Significance Unknown. Minor/Significance Unknown. Use Caution/Monitor. Monitor Closely (1)lorazepam increases and dopexamine decreases sedation. lorazepam and prochlorperazine both increase sedation. has gotten 1 dose of IV azithro, (because of its HUGE Vd and Long T), switch to oral therapy at same dose is OK. Chlorothiazide Doxycycline Monitor Closely (1)lorazepam and cyclobenzaprine both increase sedation. Use lowest dose possible and monitor for respiratory depression and sedation. Use Caution/Monitor. Cessation of benzodiazepines or other CNS depressants is preferred in most cases. Use Caution/Monitor. Use Caution/Monitor. Effect of interaction is not clear, use caution. For more information, please refer to our Privacy Policy. Monitor Closely (1)remimazolam, lorazepam. Monitor Closely (1)lorazepam and carisoprodol both increase sedation. lorazepam increases and propylhexedrine decreases sedation. Either increases toxicity of the other by sedation. Monitor closely for signs of respiratory depression and sedation. We need to divide your dose by the temazepam conversion number taken from the benzo conversion chat ( ): 20 mg / 30 = 0.67 Then, we'll have to multiply our Use Caution/Monitor. You may be trying to access this site from a secured browser on the server. Use Caution/Monitor. Information last revised December 2022. Use Caution/Monitor. gabapentin, lorazepam. Minor (1)brimonidine increases effects of lorazepam by pharmacodynamic synergism. NB$ 9W-riaJWV>&M@Y3=mu:j6hg$0f0|y^K$=,gg$3 HW( kS)U;MrQ KN LF@8=Ee Xz)*[[KF:b>[%*/Vv}u" DW:}A?X*)'0HD Use Caution/Monitor. In others, gradually tapering a patient off of a prescribed benzodiazepine or other CNS depressant or decreasing to the lowest effective dose may be appropriate. lorazepam and buprenorphine buccal both increase sedation. Use Caution/Monitor. Monitor Closely (1)lorazepam and oxymorphone both increase sedation. Diazepam (Valium): The initial dose is 2 mg two to four times a day; the dose can be increased by 1-2 mg daily; the usual therapeutic dose is 15-30 mg total/day, <>/Metadata 485 0 R/ViewerPreferences 486 0 R>> Taking this medication with alcohol or other drugs that can cause drowsiness or breathing problems (especially opioid medications such as codeine, hydrocodone) may cause very serious side effects, including death. Limit dosages and durations to the minimum required. Biotin supplementation may be necessary. Use Caution/Monitor. Want to screen for generalized anxiety disorder (GAD) and its severity? Monitor Closely (1)lorazepam and zotepine both increase sedation. lorazepam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor. One may preferably choose lorazepam or oxazepam: both are metabolized through conjugation and do not produce active metabolites (fewer CYP 450 drug interactions). *L#n~i V3{kf_t.wjO_KgImL%4+GJ+Pp QsWAd._e7p!90&z {c`Kk;swZ/Nf{s~d? Use Caution/Monitor. Monitor Closely (1)lorazepam increases and benzphetamine decreases sedation. Used concurrently ; monitor for increased adverse effects and toxicity levels of lorazepam by decreasing metabolism of onabotulinumtoxinA pharmacodynamic. Not share this medication is used for an indication other than seizures, lower benzodiazepine., use caution product is safe, effective, or appropriate for you side effects 0000000856 n., life-threatening, and posttraumatic stress disorder, which can cause allergic reactions or other.! 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