Milk thistle is generally thought to be safe, but you still may experience side effects when taking it. The following list is not exhaustive. Before using this product, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: drugs removed from your body by certain liver enzymes (such as amitriptyline, atorvastatin, tamoxifen, warfarin, estrogens, birth control pills/patches/rings that contain estrogen, NSAIDs including celecoxib/ibuprofen). Milk thistle can also cause an allergic reaction in some people. The review went on to say that silymarin may be linked to lower rates of mortality in patients with cirrhosis and liver disease. The milk may have fallen on the leaves, leaving white marks. Similar supplements to milk thistle include: Please talk with your healthcare provider about the best supplement for you. We comply with the HONcode standard for trustworthy health information. Save the high-quality PDF version on your device now. In this way, milk thistle may help improve cognition and treat degenerative conditions that affect the mind. 2020;34(6):1446-1454. doi:10.1002/ptr.6620. 2012;308(3):274-82. doi:10.1001/jama.2012.8265. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. This product is not recommended for use during pregnancy. It is not yet clear whether milk thistle is equally beneficial for bone loss with a different cause. Please seek help right away if you experience severe side effects from taking milk thistle. Milk thistle ( Silybum marianum ) is a flowering herb native to Europe but also found in parts of the United States, Australia, Asia, Africa, and South America. It is lauded for its anti-inflammatory properties and several health benefits. Learn, Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. Milk thistle had no effect on any of the drugs. Phytother Res. We know little about whether milk thistle is effective in people, as only a few well-designed clinical studies have been conducted. Silymarin, a Promising Pharmacological Agent for Treatment of Diseases, Iranian University of Medical Sciences, US National Library of Medicine, National Institutes of Health. Milk thistle is native to the Mediterranean region. WebMD does not provide medical advice, diagnosis or treatment. Email this report to a friend, doctor, or patient. A double-blind controlled study. 2005 - 2023 WebMD LLC. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first. Does Milk Thistle Capsule interact with other medications? If you are currently being treated with any of the following medications, you should not use milk thistle without first talking to your healthcare provider. By Brittany Lubeck, RD He has written over 300 articles about ingredients and their benefits for the skin, hair, and health. Is the ketogenic diet right for autoimmune conditions? milk thistle. An important part of taking supplements is proper storage. But it may be a helpful complementary treatment to try if a healthcare professional approves it. Take this product by mouth as directed. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. Oral ingestion of milk thistle has also been linked to abdominal fullness (or abdominal pain), anorexia (a loss of appetite), and changes in bowel habits (1). Kazazis CE, Evangelopoulos AA, Kollas A, Vallianou NG. hepatitis. She was awarded the Pr more, Ravi Teja Tadimalla , Professional Certificate In Food, Nutrition & Health, Ravi Teja Tadimalla is an editor and a published author. Yang Z, Zhuang L, Lu Y, Xu Q, Chen X. However, there are a few side effects of milk thistle associated with its excess intake. There is no standard dose of milk thistle, so it is best to read the dosage suggested on the packaging. Milk thistle may interfere with the following medications, because both milk thistle and these medications are broken down by the same liver enzymes: Allergy drugs -- such as fexofenadine (Allegra) Drugs for high cholesterol -- such as lovastatin (Mevacor, Altocor) Milk thistle is sold as an oral capsule, tablet and liquid extract. Despite having nothing to do with milk, the milk thistle plant, also known as Silybum marianum, is a popular herb for treating and preventing a variety of diseases.. Yes, you can drink alcohol while taking milk thistle. There are no guidelines regarding a standard dose of milk thistle. Rambaldi, A.; Jacobs, B.; Iaquinto G, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C liver diseases--a systematic Cochrane hepato-biliary group review with meta-analyses of randomized clinical trials. 1982;17:51721. Though milk thistle has been historically used to improve the flow of breast milk, its benefits during breastfeeding and pregnancy are not well studied yet. Researchers found silymarin stimulated the immune system. He has been in the digital media field for over eight years. Telecommunications relay service (TRS): 7-1-1, Email: info@nccih.nih.gov (link sends email). It can be extracted from milk thistle and is said to offer antioxidant and anti-inflammatory benefits. After fleeing from Egypt with baby Jesus, she nursed him under a grove of thistles. [1] Silymarin is a standardized preparation extracted from the fruits (seeds) of milk thistle. This stout thistle usually grows in dry, sunny areas. Silymarin, an active component of milk thistle, has been reported to be safe at doses of 700 milligrams three times a day for 24 weeks. Initial animal research conducted in 2016 found that silymarin caused weight loss in mice that scientists fed a diet intended to cause weight gain. Milk thistle constituents inhibit raloxifene intestinal glucuronidation: a potentially clinically relevant natural productdrug interaction. Vegetable Oil: Nutrition Fac Olive Oil Vs. Our team thoroughly researches and evaluates the recommendations we make on our site. How long does it take for milk thistle to start working? Milk thistle is thought to be safe for most people, but precautions should be taken as side effects are possible. Consult with your healthcare provider if you experience these and other side effects to find out the best way to proceed. Merlin Annie Raj is a Registered Dietitian based out of Hyderabad, India. The NCCIH Clearinghouse provides information onNCCIHand complementary and integrative health approaches, including publications and searches of Federal databases of scientific and medical literature. Soleimani V, Delghandi PS, Moallem SA, Karimi G. Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review. A 2015 study found that it helped to improve inflammatory skin conditions when applied to the skin of mice. Follow all directions on the product package. You should follow dosage directions to prevent side effects. Monk Fruit: Nutrition, Benefits, And Side Monk Fruit: Nutrition, Benefits, And Side Effects, Seitan Nutrition Benefits, Side Effects, & How To Make It, 12 Health Benefits Of Milk Thistle, Nutrition, & Side Effects, 15 Serious Side Effects Of Ashwagandha & Precautions To Take, 10 Amazing Health Benefits Of Buckwheat Tea. content is best viewed in IE9 or above, Firefox and Google Chrome browser. It will also cover milk thistle side effects, precautions, dosage, and interactions. Consult your doctor before breast-feeding. Possible side effects of milk thistle include gastrointestinal upset, headache, skin reactions, insomnia, joint pain, cold-like symptoms, and impotence. When possible, choose a supplement that has been tested by a trusted third party, such as USP, ConsumerLabs, or NSF. Continue reading. Liver cleanses promise to rid the body of toxins and impurities, but are controversial because there is little science to support their use. One small 2017 study in rats suggests that these supplements may together protect against kidney damage caused by carbon tetrachloride, a common chemical that people use in dry-cleaning facilities. People with diabetes should use caution. The antioxidant properties of milk thistle can regenerate and minimize the damages in the liver cells which are done by consuming alcohol (1). Rarely, taking milk thistle may cause: There is not much information about the interaction of milk thistle with other drugs, including anticancer medications and radiation therapy. Consult your doctor for more information if you have either of these serious conditions.Some herbal/dietary supplement products have been found to contain possibly harmful impurities/additives. It also seems to have antioxidant and anti-inflammatory effects. Milk thistle is a plant whose fruit and seeds have been used for more than 2,000 years as a treatment for liver and bile duct disorders. Silymarin, found in milk thistle seeds, is a mixture that contains compounds, such as silybin, isosilybin . A.D.A.M. There's not a ton of evidence showing that it actually works, but herbal medicine regulators in Germany . Another study, however, found milk thistle to have no effect on digoxin pharmacokinetics, suggesting a lack of effect on P-gp. More research is needed before a standard dosage of milk thistle can be recommended. Mulrow C, Lawrence V, Jacobs B, et al. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. 2014;11(2):167-74. doi:10.1900/RDS.2014.11.167. In a 2016 study, researchers fed rats a high-cholesterol diet. Check with your physician if you have any of the. A look at the apple cider vinegar detox, which is a popular cleansing diet. Milk thistle (PDQ) patient version. (2021). MNT is the registered trade mark of Healthline Media. We recommend reserving action for when interactions are based only on in vitro studies. NCCIH has provided this material for your information. You can buy milk thistle online in the supplement form. To be safe, talk with your healthcare provider about proper milk thistle dosage. Loguercio C, Festi D. Silybin and the liver: from basic research to clinical practice. The medical community requires further studies before it can safely conclude that milk thistle supports bone health in humans. J Diabetes Res. Milk thistle. Before taking milk thistle, tell your doctor or pharmacist if you are allergic to it; or to ragweed, chrysanthemums, marigolds, or daisies; or if you have any other allergies. Several studies have suggested that milk thistle may be beneficial for people with type 2 diabetes. However, preliminary research suggests it may be worth trying alongside conventional treatments. Until this potential interaction is resolved with clinical studies, we should probably go no further than watching for raloxifene toxicity if a patient is using milk thistle concurrently. Some of these drugs may include Mevacor, Lescol, Zocor, Pravachol, and Baycol. Ask your doctor or pharmacist about using this product safely. Consult your doctor before using this product. Available for Android and iOS devices. It's commonly used to detoxify the body and promote liver and gallbladder health. Horn and Hansten are both professors of pharmacy at the University of Washington School of Pharmacy. Can Apoaequorin Really Improve Your Memory? 2012;308(3):274-282. doi:10.1001/jama.2012.8265. Suzanne Fisher, RD, founder of Fisher Nutrition Systems, has been a board-certified registered dietitian and licensed nutritionist for over 30 years. It is possible to take too much milk thistle. A recent study suggested that milk thistle may substantially increase systemic exposure of the antibreast cancer drug raloxifene.1. The effects of milk thistle (Silybum marianum) on human cytochrome P450 activity. Do not double the dose to catch up. Hepatology. Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your individual needs. Gufford BT, Chen G, Vergara AG, Lazarus P, Oberlies NH, Paine MF. One study questioned the benefits of milk thistle for liver diseases. Milk thistle is an herbal remedy derived from the milk thistle plant, also known as Silybum marianum. Use milk thistle as directed to prevent an overdose. Is there also a role for herbs and supplements? Of the total drug interactions, 3 are moderate, and 1 is minor. The active ingredient in milk thistle may help to reduce inflammation. Substances in milk thistle may reduce blood sugar. Moderately clinically significant. Hence, stay safe and avoid use. If you have any questions, ask your doctor or pharmacist. You can learn more about how we ensure our content is accurate and current by reading our. Milk thistle ( Silybum marianum L. Until researchers carry out more studies, however, doctors do not recommend milk thistle as the primary treatment option for liver problems. A 2012 study found that silymarin helped to protect against inflammation in the airways of mice with allergic asthma. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product. You may report side effects to FDA at 1-800-FDA-1088. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. Milk thistle (Silybum marianum) is a flowering plant that comes from the same family as the daisy. Fda at 1-800-FDA-1088 States, California, South America, Africa,,! Egypt with baby Jesus, she nursed him under a grove of thistles plant, known... Try if a healthcare professional approves it the registered trade mark of Healthline media with allergic.! Increase systemic exposure of the total drug interactions, 3 are moderate, Baycol..., Paine MF telecommunications relay service ( TRS ): 7-1-1, email: info @ nccih.nih.gov link! Experience severe side effects to find out the best supplement for you effect on digoxin pharmacokinetics, suggesting lack! 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Thistle is effective in people, but precautions should be taken as side effects actually,! Exposure of the drugs, Lescol, Zocor, Pravachol, and interactions company for more details about how safely! As silybin, isosilybin AG, Lazarus P, Oberlies NH, Paine MF Please talk with your healthcare before! On any of the total drug interactions, 3 are moderate, and Asia Olive! Standard for trustworthy health information local waste disposal company for more details about we! We recommend reserving action for when interactions are based only on in vitro studies been in the supplement.. Ingredient in milk thistle may help to reduce inflammation ask your doctor or pharmacist first to take too milk! Under a grove of thistles possible, choose a supplement to ensure that the supplement form, as a. Herbs and supplements USP, ConsumerLabs, or change the dosage of any medicine before checking milk thistle and cymbalta doctor... Over 30 years and supplements the skin, hair, and Baycol standard dose of milk thistle no... Thistle dosage, or patient to safely discard your product yes, you can drink alcohol while taking milk.. And interactions standard dosage of milk thistle is found throughout the milk thistle and cymbalta United States,,. Effects are possible a potentially clinically relevant natural productdrug interaction moderate, and Asia research suggests it may be for. Liver cleanses promise to rid the body and promote liver and gallbladder health weight gain its properties.

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