She is shaking and panting heavy. all my dogs were prescribed and my eldest dog has had a strange reaction hives all over his body, panting, restless started same night he took the pill but has had the product on previous occasions with no side effects but this time he had a that reaction,had to administer meticam for the pain and antihistamines for the hives - he is still not right after 4 days and my other dog louie has always suffered from seizures since a pup vet say possible epilepsy - managed without medication at present and I do always try to avoid medication with him as they always make his seizures worse - I am so angry for not researching this further before .. All they care about is the money and not the animal. Although the mother that took the same had not shown any effects. High on the list was Simparica Trio. Today started diarrhea & he has gone 5 times so far while not eating much. This is taken from the article printed above all these comments "Simparica works by impacting the nervous system of invertebrates such as fleas and ticks. She is lethargic and doesnt want to eat. I feel like this drug was pushed by my vet tech and veterinarian. Simparica has an active ingredient called Sarolaner. This is still going on weeks later. These two neurotoxins are so effective because they prevent adult fleas from reproducing, and they kill the other stages of fleas, from egg, larvae, and pupae. Revolution is a much safer flea treatmentSimparica should not be used on dogs at all.PERIOD !whomever approved this drug needs to be sued via a class action law suitDO NOT use this drug on your dogsluckily I was made aware of this drug before using it on my precious ones as this drug had gone public and I happened to read about it..I don't know why Vets aren't warning clients about the potential serious side effects and/or possible DEATH ! Eight hours later and she has terrible diarrhea and vomiting, now she is not eating. Credit: Purple Collar Pet Photography / Getty, Simparica Trio for Dogs Might Be the Easiest Way to Protect Your Pup From Parasites. I'm more concerned about fleas and heartworms and Trifexis is just fine for that. Before he took his first doe of Simparica he was fast running, and flying through the house and yard. I have an 8 year old Labrador. I couldnt figure it out until I googled all the medications the vet has prescribed for her then I came across this forum and I am pissed!! Instead, it kills larvae, allowing your dog to avoid infection. These neurological side effects may include muscle tremors, ataxia (loss of control of body movements), and seizures. Was hospitalized for 2 1/2 days. If I still lived in the city, I would probably use the garlic because the previous GS never had any issues and lived a long time. Not long after ingesting the chewable she began to have tremors, but not full blown seizures. Started in February and within a couple of weeks ears started twitching. I wish I would have researched this before giving it to my puppy who is only 10 weeks, he has the same symptoms . I used to use revolution but they dont cover ticks as well. I wish I would have read these comments first. She definitely is not herself and behaving strangely. The company is reimbursing for vet costs. Zoetis claims it will be out of his system in two months and I should not see lasting effects, so I am hopeful but worried and telling everyone I know NOT to use this poison. He started having skin issues that the vet said were allergic reactions probably due to environmental things. Are there any side effects to Simparica Trio? I am so angry. I gave this Simparica Trio to my dog 2 days a ago, he is 7 days short of 14 yrs of age, He would not eat and drank very little for 2 days after giving this to him Never again want my Trifecta back had no problems, I gave my precious puppy this and 12 hours later, How long did your dog have dirreha duke his pill Monday and he hasnt had a normal poop. He is 5 months old. Monday morning - 11 days after he is like a zombie - all motions are almost mechanical and when I talk to him it takes him a long while to react. During this period coincidentally I have noticed a change in his behaviour. Simparica chewable is a preventative that is better suited to healthy adult dogs living in areas where ticks are prevalent. Today June 1,2022 she is still having neurological problems. I hope for all of you that your pets (loved ones) have improved, I know the feeling of total helplessness to help them and all you can do is wait and hope. I feel like it was a massive overdose. Kristine, unfortunately my sweet Dolly passed away on October 9th. He has never acted like he was in pain. I am hoping it is almost all out of her system. She text me asking if she ever had seizures before. He took simparica trio 3 weeks ago and I cant wait until its out of his system! He was lethargic & laying in his crate alot . Serious side effects are rare, but you should still monitor your dog after administering Trifexis and report any . After being on Simparica Trio 6 months our cockapoo got extreme diarrhea and would not eat. Sarolanerstarts fighting fleas within three hours and begins to kill ticks after 8 hoursincluding the lone star tick, black-legged tick, brown dog tick, American dog tick, and Gulf Coast tick. I came across this site and read so much about symptoms that I now realize he has been having. The flea components vary but having had one seizure you're now prone to being sensitive to even the "safer" ones. I will never use this product again!!!!! He is like our baby because our son has left the nest and joined the US Navy. So sorry! It will eliminate infestations of deer or black-legged ticks, lone star ticks, Gulf Coast ticks, American dog ticks, and brown dog ticks. They won't be taking another dose, I cannot recommend this medication especially if you have a small dog. I am sure simparica caused a fatal seizure in my boxer. He was diagnosed with "Sundowners" . Simparica is available by prescription only, so discuss any history your dog has of seizure disorders with your veterinarian when determining the best flea and tick treatment for your pet. I gave this poison to my almost 3 year old Yorkie she is dying as I right this. Then things got progressively worse. This Tuesday the 17th I had given my dog simparica trio for 27lbs dose. I have my 10mth old Iggy her first dose and since having this brand she has been shaking for the last 10 days we have been to the vet she has had IV fluids to push the drug out of her system and has had valium but all with minimal affect!!! Today she has fallen 2 or 3 times in the last 8 hours). It's not worth the risk of additional seizures or other neurological effects, and it seems that his stumbling and getting tired sooner on walks are likely related. My 5 year old, healthy Australian Shepherd had a check-up + boosters at the vet on January 24th. She has been diagnosed with thyroid problems and myocarditis. She has been itching uncontrollably since I gave her the simparica. Too many symptoms to list but a few days ago he started crying out in pain for no obvious reason. I thought it was them not liking the food and made a change. So sad as he was once a happy healthy dog with no prior health issues. Vet did not recognize symptoms of unary issue and thirst 2 weeks after starting on this drug combo. It is really eye-opening to see everyone's experiences. I really hope that all of the dogs of everyone who has received medication and are now ill have a full recovery. Simparica, Nexgard, Bravecto and Credelio are part of a group called Isoxazoline drugs. I even told them about the Simparica which they dont respond to. Started our 8 month old rescued golden retriever on simpatico trio in February as had our rescued border collie mix on it for last year. About 11 months ago our vet recommended Simparica Trio. Shame on you! Hard fast shaking and terrified eyes. First time for this adverse reaction. I want to thank everyone who posted I could not find enough information on other sites. All the swelling went down immediately and the itching went away too. Insurance for dogs, cats, and other household animals can run as low as $20 a month, but that cost can add up over time. Ours lasted about a week. I took him to the ER they checked his vitals and sent me home. So this month. He licks his lips all the time? It has been 20 days since I gave her the prescribed dose of Simparica. For those who lost their dear companions from this medicine my heart goes out to you all. My dog is on a "health care plan" with my vet. Saturday he started up the drinking again and threw up his breakfast. My dog is having the same issues. My little Billy Boy had his first visit to the vet and they gave him Simparica Trio. I will be speaking to vet to switch to something else. Thank u Fox I have good news I did get 2 additional in house potassium test done and they both came back normal. Millions of dogs take flea and heartworm meds without side effects but that's not to say it doesn't happen or that an alternative would be safer. The next day Bellas stools were quite soft but still had some structure. But unfortunately it's only a dog is the big Pharma tune. She never did that before! It may be that he is getting older as he is now one years old and he was neutered about three months ago. Its Sunday night and still vomiting. Head bobbling and hind legs unable to support her - as if she were really drunk. Although much improved, she continues to exhibit left side bias, with frequent left circling. I had placed an order with Pet Meds for the prescription before I saw any of these side effects.I will be returning this medication and order Heartgard and not sure what we will do for flea and ticks, since he turns his nos Simparica Trio, e to the Nexgard and we really dont feel safe with our Grandson around the topical or collarAny suggestions? This medication is given once a month by mouth, with or without food. Im wondering if after it is out of his system or have I now poisoned my baby where he might have a seizure disorder for the rest of his life. Currently we are monitoring him closely-hes never been sick. We gave our 3.5 month old Aussie pup a dose of Simparica today (vet's prescription), and I did not see the warnings about giving it to dogs under 6 months. Maybe dont have a dog. My husband said , get dressed were taking him in . He had no events and seemed to be a healthy and happy animal. Im trying to understand how. Circumstances changed and moved to a semi rural area in Florida surrounded by lots of woods. Pyrantel works by paralyzing worms, which are then expelled from the body in feces. My precious rescue has been sick twice, currently on her second episode. I don't give him much treat eather. Reading your comments, this drug may be the cause. I called our Vet on the second day and they said they doubted very seriously that the Simparica would have give him diarrhea, and then told me that I should wait and see what happens with the next dose, because I had also told them that he had some drippings from some ground beef over his dog food the day before I gave him that first dose. Vet suggested that I switch to Simparica Trio (he gets a kickback from the manufacturer). There is a possibility it isn't the cause, but it is the only reason I can find and it aligns with the stories of others. FDA Adverse Reaction Reports 18. Oral use. Side effects of Simparica Trio observed in safety and effectiveness studies included diarrhea, vomiting, lethargy, ear infection, polyuria, hyperactivity, and pruritus. Pharmaceuticals are killing people and pets. Simparica trio is a de-worming medication. Sarolaner is an acaricide (kills ticks and mites) and insecticide (kills fleas) belonging to the isoxazoline class of drugs. But few people read it or think it must be a million to one problem. After a day one back leg started working and after six days the other one began to have feeling in it. I'll continue to watch her. Vet put her on metronidazole which is working. Simparica Trio has been extensively tested on various breeds and on dogs of different ages. 1 is pregnant I told the vet what can I give the pregnant yorkie she said sampirica sold me a 3 month supple for her. I knew it was bad from the onset but the vet said I can't take a chance on him getting heartworms because the mosquitos are so bad not to mention fleas and ticks. I only stumbled on the side effects of this drug via a post on a Spinone group. The cardiologist found no heart condition that would cause this. Itching has decreased immensely. Seizures. I called the vet and of course they do not think it's the pill but I know it was. 2-6 days in vomiting here and there. Photo: AdobeStock/Monkey Business The FDA is warning pet parents that flea and tick medications may result in neurological issues. I just took my dog in after hes been having pain and arthritis type symptoms following Symparixor and they are saying it looks like meningitis. It sounds as if she's been pinched while sleeping although nothing visible happened. How is your puppy now after 7 months leases our 2 yr old frenchie just spent 3 days hospitalized and clearly has neurological symptoms. For Instance he has never liked grooming, I brushed him out last night and he slept through the whole thing. She still has her appetite at the moment. I'm so upset. Today he had runny stools threw up mucus Wont eat or drink (i gave him ice out of my hand and did gove him couple treats) He is lethargic also I called emergency vet and ahe said it probably is from this medication but not all dogs have these side effects. He is now acting like he has dementia, having seizures more frequently, not barking, lashing out at his dog brothers- jut not his self. Training your dog to follow basic commands builds a positive relationship with her and helps ensure her safety. My 18 month old dog has had Sim Perica trio. 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